The Indianapolis Colts (8-6) have won five of their past six games and are in a three-way tie atop the AFC South standings. They make their final regular season road trip when they face the Atlanta Falcons (6-8) in Week 16 NFL play early Sunday afternoon.The early Colts vs. Falcons odds had Indy a 2-point favorite on Sunday evening.Currently, Atlanta is favored by , the total is , and Indianapolis can be had for on the moneyline.On the ATS board, Indianapolis is tied atop the chart with a 9-5 record; the Falcons are at 4-10, including six lo ses as the betting favorite.As for over/under results, Indianapolis has been involved in 10 games that went over the total. As for Atlanta, 10 of its 14 games have gone under.Here's the latestfor Colts vs. Falcons:This is the first meeting between the teams since 2019.In their Willie Gay Jr. Jersey series history, the Colts hold a 15-2 advantage, including a 19-7 victory over Atlanta in the Falcons' inaugural year in 1966. According to Gold Sheet data, the Colts were 28-point favorites in their first matchup, the highest point spread in an NFL game dating to 1957.This will be Atlanta's last home game of the regular season, where the Falcons are 4-3. For the second time this season, head coach Arthur Smith has benched opening-day starting QB Desmond Ridder in favor of Taylor Heinicke.Indy, meanwhile, has a 5-2 record in the enemy's home stadium. That matches the most road victories for the Colts in the previous 13 years.Here is the current injury report for the Colts vs. Falcons:The Colts' top two running backs, Jonathan Taylor and Zack Mo s, and top receiver Michael Pittman Jr. all hope to Jack Tatum Jersey play. But will they? All were listed as questionable early in the week.Mo s and Pittman were injured last week. Taylor has been out for the past two weeks.The Falcons are most concerned with getting back their starters along the right side of the offensive line. Guard Chris Lindstrom and tackle Kaleb McGary mi sed last week's 9-7 lo s to Carolina and are questionable for this week.Although QB Gardner Minshew is only 21st on the pa ser-rating chart, he's kept the offense moving. Last week, he had three touchdown pa ses in their 30-13 home victory over Pittsburgh after Indy spotted the Steelers a 13-0 lead.Over his past three games, Minshew had six TD pa ses and one interception. Before this most recent stretch, he had six TDs and seven INTs in six games.As for the running game outlook, the status of Taylor (thumb) and Mo s (shoulder) is paramount. In their place last week, backup Trey Sermon had 88 yards on 17 carries in the first significant stretch of playing time for the third-year RB.Heinicke has played in three games this season, including two starts, and Atlanta lost J.J. Nelson Men Jersey all three. He left his last game six weeks ago -- a 25-23 lo s at Arizona -- with a hamstring injury and hasn't thrown a pa s in a game since.Only two weeks ago, heading into Week 14 play, the Falcons were favorites to win the NFC South (-175 BetMGM). But after ensuing lo ses to Tampa Bay and last-place Carolina (arrgghh!), the Falcons are one game off the pace in the division and the wild-card race.That doesn't seem like a mountain to climb, but PlayoffStatus.com lists the Falcons' chances to make the playoffs at 8 percent.Let's look at some prop bets for the Colts vs. Falcons atnationwide.Colts vs. Falconsanytime TD scorer ()Trey Sermon (-140)Bijan Robinson (-120)Zack Mo s (-120)Michael Pittman Jr. (+145)Tyler Allgeier (+160)Josh Downs (+190 John Miller Jersey )Drake London (+210)Kyle Pitts (+210)Taylor Heinicke (+240)Alec Pierce (+310)Gardner Minshew (+450)Colts vs. Falcons Alternate Point Totals ()Over 20.5: -20000Under 20.5: +2200Over 28.5: -1600Under 28.5: +750Over 36.5: -340Under 36.5: +250Over 52.5: +260Under 52.5: -360Over 60.5: +680Under 60.5: -1400Colts vs. Falcons Three-Way Moneyline ()Colts win: +100Tie: +5500Falcons win: -115Although the Falcons were embarra sed in their lo s to the 1-12 Panthers last week, the defense held Carolina without a touchdown.That unit is ranked 10th in the league in yards yielded and has allowed only five rushing TDs this season, second only to the four allowed by AFC juggernaut Baltimore.With the Colts' running game likely not going to be up to speed and with the Falcons going with a veteran at QB this week, Atlanta should play a cleaner game. Plus, if Taylor plays after thumb surgery, will that injury affect his ability to protect K.J. Wright Jersey the ball?Regarding Minshew's strong game last week, bettors need to consider that he was going against a Steelers secondary that was depleted by the midgame ejection of one starter and an injury to three-time All-Pro safety Minkah Fitzpatrick.Prediction:Falcons and UNDER Date:Sunday, Dec. 24Kickoff:1 p.m. ETLocation:Mercedes-Benz Stadium -- Atlanta, GAWhere to Watch:Fox If you purchase a product or register for an account through one of the links on our site, we may receive compensation. Sporting News has editorial oversight for this content.