The Las Vegas Raiders, alone atop the AFC West standings, will be making their first of this season's four trips east over three time zones when they face the host Buffalo Bills in the early time slot Sunday in Week 2 of the NFL season. Lets look at Raiders vs. Bills odds, props, and predictions.In Week 1, the Raiders were one of eight betting underdogs to earn an outright victory when they rallied past the Broncos in Denver, 17-16.The Bills, meanwhile, will be working on short rest Sunday after being one of the eight favorites to tumble in Week 1. Shockingly, they were defeated 22-16 in overtime by the Jets on Monday night, after New York lost star QB Aaron Rodgers to a season-ending Achilles injury on his fourth snap with the team.Buffalo also was the only team over the weekend to squander a double-digit lead when they blew a 13-3 third-quarter edge to the Zach Wilson-led home team.The Bills are favorites of , with the Raiders offered at . The line opened at -9.5 at the Westgate Las Vegas SuperBook Mark Lowe Jersey in the spring.It's the 20th straight game Buffalo has been a favorite, going 8-10-1 ATS its previous 19 outings. On the other hand, this is the 26th time the Raiders have been a road dog since 2019, going 16-9 ATS.The Bills are available on the moneyline at , with the Raiders at .Las Vegas, despite being the only 1-0 team in its division, still has the longest odds to win the West at . Buffalo, 0-1 and behind the Jets and Miami, entered the season as the favorite to win the AFC East but now is listed as the second-choice at .With regard to the Raiders' trip east acro s three time zones, Western teams were 6-5-1 ATS in that scenario last season and 15-6 the year before. But, dating to the 2021 playoffs, the Raiders have gone 0-3 in such games.As for clubs coming off a MNF game and playing the next Sunday against a team on at least normal rest, Duke Snid Jersey teams were 13-17 ATS in the 2022 season, including playoffs.Neither team had a player on its injury list early in the week, but that doesn't mean the clubs don't have i sues.A big concern for Las Vegas is WR Jakobi Meyers. The ex-Patriots receiver was in concu sion protocol early in the week after taking a hit against the Broncos. He had caught nine of 10 targeted throws at Denver and scored both Raiders TDs.Then there's veteran defensive end Chandler Jones, who's having friction with Custom Jersey management and was inactive last week for personal reasons. His availability for Sunday reportedly is uncertain.And safety Tre'von Moehrig was knocked from the Denver game with a thumb injury. Some websites list him as questionable.For Buffalo, safety Damar Hamlin, who suffered cardiac arrest during a game vs. Cincinnati late last season, was a healthy inactive for Week 1. When he returns to action is uncertain.Also, linebacker Von Miller, one of the league's all-time best pa s rushers, remains on the PUP list and must sit out games until Week 5.Here are some other interesting ways to bet on Sunday afternoon's game:Halftime Moneyline/Full-Time Moneyline Winners (DraftKings)Raiders/Bills: +700Raiders/Raiders: +500Raiders/Tie: +3000Tie/Bills: +1600Tie/Raiders: +3000Tie/Tie: +7000Bills/Bills: -190Bills/Raiders: +1200Bills/Tie: +3000First Score of Game (FanDuel)Raiders TD: +310Raiders FG: +440Raiders safety: +8500Bills TD: +110Bills FG: +400Bills safety: +10000First Touchdown Scored (FanDuel)Bills QB Josh Allen: +600Bills RB James Cook: +650Bills WR Stefon Diggs: +650Raiders RB Josh Jacobs: +850Bills RB Damien Harris: +1100Bills WR Gabe Davis: +1100Raiders WR Davante Adams: +1100Raiders WR Jakobi Meyers: +1700Raiders WR Hunter Renfrow: +1700Buffalo QB Josh Allen is coming off one of the worst games of his six-year career, throwing three INTs for only the third time, Ross Stripling Jersey fumbling twice (losing one) and getting sacked five times. The Bills wound up with a minus-3 turnover differential that almost always spells doom since teams with that margin went 1-27 last season.But being foiled by the Jets isn't new to the Bills' star QB, for last year he had his worst game of the season in a lo s to the Jets in the Meadowlands, when he also was sacked five times -- a regular-season-high -- and his team blew a double-digit lead.Although the Bills' defense held the Jets to 16 points Monday, their run defense looked awful at times in yielding 172 ground yards -- the same number Buffalo allowed in its 27-10 beat-down home lo s to Cincinnati in last year's division round. But 83 of the Jets' rush yards came on an early run by speedy Breece Hall between the tackles. Disregarding two kneel-downs to end halves and that long run, New York's norm was only 3.6 a carry.The Raiders should be a welcome sight to the Buffalo defense.Last week, many analysts didnt think Vegas would be able to run against Denver. They were right. The Raiders averaged only 2.1 yards a carry, the lowest norm for any team in Week 1. Last year's rushing champ, Josh Jacobs, gained only 48 yards on 19 carries (2.5 average) with a long of 7 yards. The holes just weren't there.On the other hand, at least Vegas' offensive line helped keep QB Jimmy Garoppolo from being sacked.Where the Raiders seem to be most vulnerable is getting off the field on defense. On the Broncos' first five drives last week, they totaled 57 plays and 22 first downs. Vegas didn't make quick work of Denver until the Broncos' final po se sion as they scrambled to get the lead.In summary, Allen surely learned a le son in not being carele s with the ball and with his body, which included helicopter leaps over defenders when a first down wasn't in reach. Also, that Buffalo secondary should be able to foil Garoppolo, who had a reckle s interception into the end zone late in the game that almost was costly to the Raiders.Picks: Bills and underHow to Watch Raiders vs. BillsDate: Sunday, Sept. 17, 2023Kickoff: 1 p.m. EDTLocation: Highmark Stadium Orchard Park, NYWhere to Watch Albert Pujols Jersey : CBS If you purchase a product or register for an account through one of the links on our site, we may receive compensation. Sporting News has editorial oversight for this content.